Reprogramming ‘support cells’ into neurons could repair injured adult brains — ScienceDaily

The portion of the adult brain responsible for complex thought, known as the cerebral cortex, lacks the ability to replace neurons that die as a result of Alzheimer’s disease, stroke, and other devastating diseases. A study in the International Society for Stem Cell Research’s journal Stem Cell Reports, published by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2 glia, to turn into neurons in the injured cerebral cortex of adult mice. The findings reveal that NG2 glia represent a promising target for neuronal cell replacement strategies to treat traumatic brain injury.

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Reprogramming ‘support cells’ into neurons could repair injured adult brains — ScienceDaily.

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Gene therapy provides safe, long-term relief for patients with severe hemophilia B — ScienceDaily

Gene therapy developed at St. Jude Children’s Research Hospital, University College London (UCL) and the Royal Free Hospital has transformed life for men with a severe form of hemophilia B by providing a safe, reliable source of the blood clotting protein Factor IX that has allowed some to adopt a more active lifestyle, researchers reported. The results appear in the November 20 edition of The New England Journal of Medicine.

In this study, participants received one of three doses of gene therapy that used a modified adeno-associated virus (AAV) 8 as the vector to deliver the genetic material for making Factor IX. The vector was administered as a single infusion into a peripheral vein in the arm of each participant.

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Gene therapy provides safe, long-term relief for patients with severe hemophilia B — ScienceDaily.

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Scientists prevent memory problems caused by sleep deprivation — ScienceDaily

In a new study, published in the Journal of Neuroscience, a team led by scientists from the University of Pennsylvania found that a particular set of cells in a small region of the brain are responsible for memory problems after sleep loss. By selectively increasing levels of a signaling molecule in these cells, the researchers prevented mice from having memory deficits.

Robbert Havekes was the lead author on the study. He is a research associate in the lab of Ted Abel, the study’s senior author and Brush Family Professor of Biology in Penn’s School of Arts & Sciences. Coauthors from the Abel lab included Jennifer C. Tudor and Sarah L. Ferri. They collaborated with Arnd Baumann of Forschungszentrum Jülich, Germany, and Vibeke M. Bruinenberg and Peter Meerlo of the University of Groningen, The Netherlands.

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Scientists prevent memory problems caused by sleep deprivation — ScienceDaily.

source - http://www.sciencedaily.com/

Four examples of the symbiosis between design and technology

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Originally posted on Gigaom:

One of the big themes at Roadmap 2014 was the integration of design and technology. Speakers discussed everything from how designers and developers should work together to whether technical restraints hurt or help the design process.

Tim McCoy, the director of product design at Pivotal Labs, gave a brief presentation Wednesday on the history of technology and design butting up against each other. He went through a list of designers and companies in the last 600 years who grappled with the space between the two. Here are some of the most compelling examples:

  1. Frank Lloyd Wright: Wright was an experimental designer who would frequently release design-focused structures that didn’t always hold up. He was loath to compromise his vision for practicality. At one point, Hib Johnson, president of the company Wright worked for, decided to persuade the architect using a hands-on example — he asked him to reach for something…

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Three Surprisingly Easy Ways to Improve Your Language-Learning

Originally posted on Some Kernels of Truth:

Have you ever studied another language, only to hit a wall you can’t seem to get past in terms of your comprehension? I have too; I studied French and Spanish from junior high school through college, and beyond on my own, yet I’ve gotten rusty in both and struggle to really speak and understand either the way I feel I should by now.

But I’ve come up with a few strategies to improve my abilities in both languages, and wanted to share them with you in the hopes you’ll benefit from them too.

I’m not talking about the common tips, like to practice, practice, practice — sure, do that whenever possible. But we already know that, yet many of us still struggle to get to an intermediate level in our language(s) of study.

I also won’t suggest classes — again, nothing wrong with that approach, but I’m assuming that many…

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Riding the tide of a great story

Originally posted on Live to Write - Write to Live:

Quick check-in with the NaNoWriMo-ers. Continuing to plug away? There’s still time to hunker down and create your masterpiece, you just have to want it bad enough to set aside the time to “just do it” (and besides, wasn’t that what nights were invented for?)

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Zelda as a hen (Version 1.0)

I have been pecking away at my project and currently have around 23,000 words, but not to worry. I’ve been known to add up to 10,000 at one (crazy) sitting. And, I’m the type of person who thrives on a deadline – so it’s all good.

But today I want to talk to the article writers out there. You know the ones who write for magazines, newspapers, and even blogs (or those that hope to someday.)

As many of you know, I have a flock of chickens and I write about my chickens for several publications and on my…

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